Not all monitors can reproduce accurately the colors chosen for your web design. By staying within the recognized 216 "browser-safe color selections", you can be sure that the colors chosen will display without change. This is especially important to vision-impaired viewers, because degrees of hue, lightness, and saturation can be less distinguishable, leading to problems when the colors are being used as primary indicators.
Color blindness, also called color vision confusion, can create frustration for internet users. Most people with this condition cannot differentiate between red and green, although yellow-blue confusion is also a possibility. A small population cannot distinguish any color, seeing the world only in shades of grey and black. These internet users need other clues, such as icons and/or extra text. Red and green should never be used together, especially for navigation buttons or maps. By de-saturating (removing all color from) your webpage, you can more clearly see what your color blind audience will be viewing.